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KMID : 0366919900020010055
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Sungkyun Pharmceutical Journal
1990 Volume.2 No. 1 p.55 ~ p.60
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Cholinergic and Cholinesterase Inhibiting Action of Histamine H_2-Receptor Antagonists
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Cho Tai-Soon
Choi Won-Chul
Lee Beom-Koo
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Abstract
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The effects of histamine H_2-receptor antagonist on acetylcholinesterase activities in human serum and erythrocyte were studied. AChE estimated from median inhibitory dose was in the following order of decreasing activities; ranitidine〉cimetidine〉famotidine.
In the studies of isolated guinea-pig ileal muscle contraction, cimetidine and famotidine showed no effect, but ranididine exhibited potent stimulating effect on contraction whose pattern was simillar to the physostigmine and blocked by atropine and pyrilamine but not by hexamethonium. Cimetidine and famotidine has no effects on the ACh and histamine activites, on the otherhand, ranitidine augmented ACh activity but not histamines.
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